Mechanical ventilation may damage organs other than the lungs

Tidal volume for mechanical ventilation of healthy lungs

Intermittent Positive Pressure Ventilation (IPPV) at our days is the gold standard treatment for patients requiring mechanical ventilation during general anesthesia and intensive care.1 The principal goals of IPPV are: improve tissue oxygenation, reduce hypercapnia and the related respiratory acidosis and reduce the work of breathing of the patient.1 Despite its important therapeutic functions,...

Presence of asbestos bodies in organs other than the lung.

This study was designed to test the hypothesis that subjects with many asbestos bodies in their lungs at autopsy would also have asbestos bodies in various other organs. The subjects included 19 cases with diagnosis of asbestosis at death (two of these had mesothelioma, five had lung cancer) and 18 with pleural plaques but not asbestosis. Occupational histories were obtained from relatives. In ...

Open the lung with high-frequency oscillation ventilation or conventional mechanical ventilation? It may not matter!

The 'open lung' approach has been proposed as a reasonable ventilation strategy to mitigate ventilator-induced lung injury (VILI) and possibly reduce acute respiratory distress syndrome (ARDS)-related mortality. However, several randomized clinical trials have failed to show any significant clinical benefit of a ventilation strategy applying higher positive end-expiratory pressure (PEEP) and lo...

Mechanical ventilation may not be essential for initial cardiopulmonary resuscitation.

BACKGROUND In a rodent model of cardiac arrest and resuscitation in which the inspired gas mixture was enriched with oxygen, resuscitability and survival were unaffected by positive pressure ventilation. In the present study, in a larger animal model, tidal volumes generated during precordial compression and with spontaneous gasping were quantitated. METHODS Domestic pigs with an average weig...

The other organs